Abstract
Objective: To determine common coagulation
disorders like abnormal prothrombin time/
international normalized ratio (PT/INR) abnormal
activated partial thromboplastin time (aPTT), and
decreased platelets count in patient with chronic liver
disease (CLD).
Methodology: This study included 278 patients with
CLD at Bilal Medical Trust and Hospital (BMTH) Pir
Baba from January to October 2019. Bloods sample
were collected in Ethylene diamine tetra acetic acid
(EDTA), sodium citrate and plain vacutainer for
Platelet’s count, PT and aPTT. These tests were
performed using hematology and coagulation
analyzers respectively. PT ratio was calculated along
with INR ratio.
Results: Out of 278 patients, 23 (8.3%) had normal
PT (less than 15 seconds), while 255 (91.7%) had
prolonged PT (more than 15 seconds). aPTT were
prolonged in 245 (88%) patients. 236 (84.89%)
patients had both prolonged PT and aPTT. While 164
(64%) patients had low platelets count.
Conclusion: Most of the cirrhotic patients (more than
90%) were having abnormal pictures of the
coagulation and even disturbed counts of low platelets.
Keywords: HCV, coagulation, activated partial
thromboplastin, platelets.
