Abstract
Objective: To compare the efficacy of ondansteron
versus domperidone for management of vomiting in
children with acute gastroenteritis.
Methodology: A total of 240 children of both
genders, aged 6 months to 5 years, who presented with
vomiting were allocated either of two groups; group A
and group B. Children in group A received
ondansetron and group B domperidone orally. Both
groups were followed at intervals of 6 hours and 24
hours after administration of assigned drug. Outcome
was measured as number of vomiting at 6 and 24 hours
post treatment.
Results: Out of 240 children, 198 (82.5%) completed
the study and119 (49.5%) were male and 121 (50.4%)
females. Mean age was 26.62 ± 16.30 months. Of
those 25 children who were vomiting, 15 (12.2%) were
on ondansetron and 10 (8.5%) on domperidone.
Difference was statistically non- significant (p = 0.42).
After 24 hours follow up, 27 (11.1%) children had
persistent vomiting. Of those, 27 (6%) were on
ondansetron and 21 (21.4%) on domperidone.
Statistical difference observed was significant (p =
0.01). Group A (ondansetrone) had better efficacy than
Group B (domperidone) after 24 hours followup.
Conclusion: Ondansetron was significantly better in
controlling vomiting due to acute gastroenteritis in
children compared to domperidone.
Keywords: Gastroenteritis, domperidone,
ondansetron, efficacy, children.
