Abstract
Objective: To compare the efficacy of ondansteron versus domperidone for management of vomiting in children with acute gastroenteritis. Methodology: A total of 240 children of both genders, aged 6 months to 5 years, who presented with vomiting were allocated either of two groups; group A and group B. Children in group A received ondansetron and group B domperidone orally. Both groups were followed at intervals of 6 hours and 24 hours after administration of assigned drug. Outcome was measured as number of vomiting at 6 and 24 hours post treatment. Results: Out of 240 children, 198 (82.5%) completed the study and119 (49.5%) were male and 121 (50.4%) females. Mean age was 26.62 ± 16.30 months. Of those 25 children who were vomiting, 15 (12.2%) were on ondansetron and 10 (8.5%) on domperidone. Difference was statistically non- significant (p = 0.42). After 24 hours follow up, 27 (11.1%) children had persistent vomiting. Of those, 27 (6%) were on ondansetron and 21 (21.4%) on domperidone. Statistical difference observed was significant (p = 0.01). Group A (ondansetrone) had better efficacy than Group B (domperidone) after 24 hours followup. Conclusion: Ondansetron was significantly better in controlling vomiting due to acute gastroenteritis in children compared to domperidone. Keywords: Gastroenteritis, domperidone, ondansetron, efficacy, children.

Muhammad Bilal Iqbal, bilal ali anjum. (2022) Comparison of efficacy of ondansteron versus domperidone for management of vomiting in children with acute gastroenteritis, , Volume 47, Issue 2.
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