Abstract
Objective: To assess the hepatoprotective effects of Ivy leaf extract in order to overcome the hepatotoxicity induced by isoniazid in rabbits. Methodology: This analytical experimental study was carried out at animal house in the Department of Pharmacology, Karachi University. The duration of the study was 60 days. A total of 30 healthy rabbits were divided randomly into three equal groups. Group I or control group, group II isoniazid (INH) group while in group III combined effects of isoniazid and Ivy leaf extract. Serum alanine transaminase (ALT) level was measured. ANOVA test followed by post hoc multiple comparison was applied to assess the difference between the groups. Results: There was significant difference in the mean level of ALT at Day 7 between the groups (p = 0.001). A significant difference was observed between the groups at day 30 and 60 (p < 0.001). Multiple comparisons of ALT level at day 60 showed significant increase between group I and group II (p < 0.001), significant difference was observed between group I and group III (p = 0.042), whereas significant decreased was observed between group II and group III (p < 0.001). Multiple comparisons of total bilirubin level at Day 60 in different groups revealed significantly increased level between group I and II (p < 0.001) as well as between I and III (p = 0.012) and between group II and III (p = 0.002). Conclusion: The oral administration of Ivy leaf extract produced a hepatoprotective effect in isoniazid induced liver injury by reducing the serum glutamate oxaloacetate transaminase level. Keywords: Hepatotoxicity, Isoniazid, serum alanine transaminase, hepatoprotective effect

Shahid Ali, Mohammad Anwer Bangulzai. (2022) Hepatoprotective effects of ivy leaves extract in isoniazid induced hepatotoxicity in rabbits, , Volume 47, Issue 2.
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