Abstract
Objective: To identify the relationship of common
serotypes of dengue virus in our region with
hematological changes in dengue patients.
Methodology: This observational study was
conducted at Isra University Hospital, Hyderabad and
included 100 cases of dengue fever. Dengue virus
antibodies were confirmed by using dengue virus rapid
test. Serotypes of virus were confirmed by
immunofluorescence test. Hematocrit (HCT), total
leukocyte count (TLC) and platelet count were
determined.
Results: The association of majority of common
clinical presentation with dengue serotypes was found
as non-significant except bleeding, which was found
significant. The association of TLC was found
significantly associated with severity of serotype.There
were only two cases of serotype III and both cases
were found with decreased TLC. Thrombocytopenia
was significantly associated with serotype. However
no significant difference was found between
hematocrit values and serotype of dengue virus.
Conclusion: Bleeding was only clinical presentation
associated significantly with dengue serotypes. The
low platelets count and TLC were also significantly
associated with severity of dengue serotype. Patients
with serotype III had severe thrombocytopenia.
Keywords: Dengue virus, serotype,
thrombocytopenia, total leukocytes count.
