Abstract
Objective: To compare clinical efficacy of 1%
metformin and alendronate gel in adjunct to scaling
and root planning (SRP) on clinical and biochemical
parameters in patients having moderate localized
chronic periodontitis.
Methodology: In this randomized open label clinical
trial, 60 systemically healthy, males and females aged
30-50 year, diagnosed with localized moderate chronic
periodontitis were enrolled from Bahria Dental
College Hospital by convenient sampling technique.
Duration of study was 6 months. Participants with
deepest periodontal pocket depth (PPD), clinical
attachment loss (CAL), plaque index (PI) and mean
sulcular bleeding index (mSBI) were included whereas
those with history of periodontal therapy and
mouthwashes were excluded. Patients were divided
randomly into two groups each group consisting of 30
patients. Group A received Metformin 1% gel and
Group B received Alendronate 1% gel, both intrapocket with SRP at day 0. Clinical parameters were
evaluated at day 0, 45 and 90. TNFα was evaluated by
Eliza at day 0 and 90. Statistical analysis was done
using SPSS version 23.
Results: Group A showed the significant reduction in
PPD and CAL compared to group B while PI and
mSBI were found non-significant. TNFα was
significantly reduced in group A at day 90.
Conclusion: We found that1% Metformin gel
produced more beneficial effects in adjunct to SRP on
clinical and biochemical parameters in comparison to
1% Alendronate gel.
Keywords: Alendronate, chronic periodontitis,
gingival crevicular fluid, metformin, TNFα.
