Abstract
Introduction: Abnormal uterine bleeding is one of the commonest presentations in the gynecological clinic in
patients of all ages. Most of the cases are managed medically; endometrial biopsy is an important investigation to
diagnose the underlying cause after excluding the organic causes of abnormal uterine bleeding.
Objective: To determine the frequencies of various endometrial pathologies that are the cause of abnormal
uterine bleeding.
Methodology: A total of 485 cases of abnormal uterine bleeding were included in this cross-sectional study.
Patients with pregnancy related bleeding were excluded. The diagnosis was made on H&E sections and
frequencies were calculated by SPSS version 20.
Results: Most of the patients with abnormal uterine bleeding undergoing endometrial biopsy were in the age
range of 30-40 followed by 40-50 years age. The pathologies related to progesterone excess including estrogen
dominance, anovulatory cycles and disordered proliferative endometrium were the most common (39%)
underlying cause of abnormal uterine bleeding. 41% of patients had normal proliferative or secretory
endometrium. Inadequate samples were only 1%.
Conclusion: Endometrial biopsy is important diagnostic investigation to determine treatable causes of
endometrial pathologies.
Dr. Mudassira, Kiran Tauseef, Humaira Zaffar, Anum Usman, Awais Niaz. (2017) Morphological Spectrum of Endometrial Lesions, International Journal of Pathology, Vol-15, Issue 4.
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