Abstract
This work describes a simple, sensitive, rapid and economical analytical procedure for direct spectrophotometric evaluation of diclofenac sodium (DS) using aqueous medium without using a chemical reagent. Parameters like time, temperature, acidic and basic conditions and interference by analgesic drugs werestudied for a 5μg ml-1solution of DS at 276 nm. Under optimized parameters, a linear working range of 0.1–30 g ml-1with regression coefficient of 0.9998 and lower detection limit of 0.01 g ml-1was obtained. The method was applied for DS contents in tablets, serum and urine samples.
Abdul Rauf Khaskheli, Sirajuddin, Kamran Abro, S. T. H. Sherazi, H. I. Afridi, S.A. Mahesar, Munawar Saeed. (2009) Simpler and FasterSpectrophotometric Determination of Diclofenac Sodium inTablets, Serum and Urine Samples, Pakistan Journal of Analytical & Environmental Chemistry, Volume 10, Issue 1-2.
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