Abstract
Purpose: To assess the frequency of glaucoma and ocular hypertension inpseudoexfoliation syndrome.Material and Methods: This study was conducted in the Department ofOphthalmology, Liaquat University Eye Hospital, Hyderabad, Pakistan from June2011 to December 2011. Hundred confirmed cases of pseudoexfoliationsyndrome (PXS) were included in the study by non-probability conveniencesampling. Tonometry, gonioscopy, ophthalmoscopy and visual field analysiswere carried out to determine glaucoma. Data was collected by speciallydesigned proforma and analyzed by using Statistical Program for SocialSciences (SPSS, version 16.0 for Windows). The frequencies and percentagewere recorded and any association with predisposing factors was statisticallyanalyzed on chi square test. P-value of <0.001 was considered significant with aconfidence interval (CI) of 95%.Results: Out of the 100 PXS patients, 16% patients were diagnosed withpseudoexfoliation glaucoma (PXG) (CI 95%): 12% with open angle glaucomaand 4% narrow angle glaucoma. Ocular hypertension without glaucomatouschanges was detected in 9% (CI 95%) of the patients (P <0.001). PXG was morecommon after 50 years of age while ocular hypertension occurred earlier i.e. 40years. Gender (P=0.45), locality (P=0.725) and family history of glaucoma(P=0.95) were statistically insignificant risk factors for development of glaucomain PXS patients. Increased age, intraocular pressure and cup-disc ratio (16%)were significant risk factors for development of PXG (P <0.001 CI 95%).Conclusion: Increasing age, intraocular pressure and cup disc ratio aresignificant risk factors for development of glaucoma in PXS. It is recommendedthat patients over 50 years should be actively examined for glaucoma particularlythose with PXS.Keywords: Pseudoexfoliation syndrome, Glaucoma, Ocular Hypertension
Azfar Ahmed Mirza, Noor Bakht Nizamani, Mariya Nazish Memon, Sajjad Ali Surhio, Khalid I. Talpur. (2015) Glaucoma and Ocular Hypertension in Pseudoexfoliation Syndrome, Pakistan Journal of Ophthalmology, Volume 31, Issue 2.
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