Abstract
Purpose: This study aimed to investigate the relationship between intravitreal injections of Lucentis and the vitreomacular surface.
Material and Methods: Central macular thickness (CMT), LogMAR visual acuity and the presence or absence of posterior vitreous detachment (PVD) were noted in Lucentis eligible patients before commencing treatment, and 6 months after initial treatment prospectively. The paired sample t-test repeated measures ANOVA were used.
Results: Of 52 eyes analyzed, 70% were noted to have no PVD prior to injection. Of these, 55% of eyes developed PVD. Comparison of the change in CMT between PVD-induced eyes and pre-existing PVD eyes was statistically significant. PVD induction during treatment was associated with a greater reduction in CMT than in eyes with pre-existing PVD. Conclusions: The induction of PVD may have an effect on CMT in eyes injected with Lucentis, implying a potential therapeutic effect of PVD in exudative AMD.
Key words: Macular, Neovascularization, Age related macular degeneration, Lucentis
Tahir Islam, Salina Siddiqui, Murtaza Mookhtiar, Louise M. Downey, Mark T. Costen. (2015) Intravitreal Injection of Lucentis and the Vitreomacular Relationship in Patients with Exudative AMD: A Prospective Study, Pakistan Journal of Ophthalmology, Volume 31, Issue 1.
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