Abstract
Chalcones and aurones are compounds having appealing
pharmacological profile due to presence of carbonyl system. The bioscreening of 13 compounds was conducted and assessed against S.
aureus, C. albicans and E. coli by agar well diffusion method. Chalcones
analogues 1, 2, 3, 4, 5, 6, 7, and 8 were found to be inactive or
insignificant against E. coli. Chalcone analogue 9 showed moderate
activity against E. coli. Similarly, compounds, 1, 2, 3, 6, 7, 8 and 9 were
found to be inactive or insignificant against S. aureus. Analogues 4 and 5
displayed moderate bioactivity against S. aureus. Similarly analogues 1,
2, 4, 7, 8 and 9 were found to be inactive or insignificant against C.
albicans. Compound 3, 5, and 6 were found more effective against C.
albicans. Among aurones 2, 3, and 4 showed insignificant activity while
compound 1 showed significant activity against E. coli. Analogue 1
showed very effective acitivity against S. aureus. In a similar way,
analogue 3 was found to be inactive, while analogues 1, 2 and 4 showed
moderate activity against C. albicans. Overall, chalcone and aurone
analogues have been effective against selected bacteria and fungi strains
and are expected to be effective in other bioscreening studies
MUHAMMAD MANSHA, QAMAR ALI, UROOJ FATIMA DILAWARI, ABRAR HUSSAIN, MUHAMMAD TARIQ. (2019) Bio-screening of Chalcone and Aurone Analogues as Therapeutic Agents, Biologia – Journal of Biological Society of Pakistan, Volume 65 (II), Issue 2.
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