Abstract
Piper betle leaf is deep green heart shaped belongs to family Piperaceae.
This plant is used for the treatment of different diseases like diabetes,
cancer, inflammatory responses, oxidant injuries etc. in the present study
ethanolic extract of Piper betle leaf was used (300 mg/kg). Diabetes was
induced in male albino rats by using Alloxan (150 mg/kg). Glutathione
(GSH), Catalase (CAT), Malondialdehyde (MDA), Nitric oxide (NO),
micronutrients (Vitamin A, Vitamin C and Vitamin E), serum glucose level
and Advance glycation end products (AGE’s) were estimated. The results
showed that levels of the Malondialdehyde (0.087, 0.151 and 0.104
respectively), Advance glycation end products (0.026, 0.053, 0.025) and
Nitric oxide (0.07, 0.438, 0.190) were found decreased while level of the
GSH (0.184, 0.188, 0.207), CAT (0.087, 0.031, 0.091) and vitamin A
(0.196, 0.136, 0.178), E (0.199, 0.140, 0.179) and C (0.163, 0.120, 0.164)
were increased after administration of Piper betle leaf extract. Blood
glucose level was also found to be decreased. It is concluded that Piper
betle leaf can be used as antidiabetic drug because it is involved in
lowering the blood glucose level and Piper betle leaf is a good source of
anti-oxidants.
HAFIZ MUHAMMAD ARSALAN, SUMMARA TABASSUM, MUHAMMAD SHERAZ YASIN, FAROOQ SALEEM, ZEEMAL SEEMAB AMIN, MUNIB ASHFAQ, UMAR FAROOQ GOHAR , RASHIDA BASHIR. (2019) Evaluation of antioxidative and antidiabetic potential of piper betle leaf in alloxan induced diabetic albino Rats, Biologia – Journal of Biological Society of Pakistan, Volume 65 (II), Issue 2.
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