Abstract
Cancer is a life-threatening disease which is emerging as a major
problem in the field of medicine. Different methods are being used to
eradicate cancer including chemotherapy, radiotherapy, immunotoxins,
and drug therapy but these treatments cause various side effects to the
cancer patients, as they not only target cancer cells but also cause harm
to normal body cells. At present some live bacteria, bacterial products,
and bacterial proteins are used to treat cancer. One of the amazing
bacterial protein azurin can work as an anti-cancerous agent which only
target cancerous cells and do not cause any harm to healthy cells and
thus minimize the risk of adverse side effects. The interaction of azurin
with P53 (tumor suppressor protein), Eph/ephrin receptor and Cadherin
enhances the activity of azurin by inducing apoptosis in cancerous cells,
disrupting signaling among cancerous cells and inhibiting the growth of
cancerous cells as well as suppressing the activity of tumor cells. This
review article focuses on the activity of the bacterial protein azurin as an
anti-cancer agent and also the properties of azurin which makes it one of
the preferable anti-cancerous agent over the other cancer treatments like
chemotherapy and radiotherapy.
ASMA ZAFAR, MONIBA KHAWAR, MAHNOOR CHAUDHRY, SAYYEDA SANA BATOOL, AMJAD HUSSAIN , & MUSHTAQ AHMAD SALEEM. (2019) Azurin: A Hardcore Anti-Cancer Agent, Biologia – Journal of Biological Society of Pakistan, Volume 65 (I), Issue 1.
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