Abstract
Avian HEV (aHEV) has been considered as causative agent of hepatitissplenomegaly syndrome (HSS) in chickens. Like other HEV strains, it is
single-stranded positive sense RNA virus belonging to Hepeviridae. In
the present study we report partial structural homology of ORF3 encoded
protein (ORF3P) of Pakistani novel aHEV (Pak naHEV) strain with a
kinase 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (HPPK) which participates in folate biosynthesis in bacteria.
This finding is in agreement with the role of ORF3P as multifunctional
protein modulating host cell signaling and gene expression to promote
viral replication during infection
TAHIR IQBAL, UMER RASHID, MUHAMMAD IDREES3. (2018) Structure prediction of ORF3 encoded protein of a novel Pakistani avian hepatitis E virus strain, Biologia – Journal of Biological Society of Pakistan, Volume 64 (II), Volume 64 (II).
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