Abstract
Nourishment in fetal life effects metabolism, growth, and development of nervous system and may lead
to major illness courses such as hypertension, obesity, diabetes and cardiovascular disorders. Obesity is a lowstandard systemic inflammatory ailment. Central adiposity measured through skin folds, waist to hip ratio (WHR)
and waist circumference (WC) is closely associated with unfavorable lipids and lipoproteins. C-reactive protein
(CRP) and fibrinogen are essential biomarkers of inflammation. In the present study, two groups: obese (n=35)
and normal (n=25), were considered. CRP was determined quantitatively by ELISA and plasma fibrinogen by
Clauss method. Serum lipid profile for low density lipoproteins, cholesterol, triglycerides and high density
lipoproteins was measured by commercially available kits. Anthropometric parameters including waist to height
ratio (WHtR), waist circumference, diastolic blood pressure (DBP), systolic blood pressure (SBP), fasting
glycemia and pulse rate showed significant increase, whereas, Waist to hip ratio (WHR) showed non-significant
decrease. CRP and fibrinogen were observed to be significantly high in obese subjects. Cholesterol,
triglycerides, VLDL, LDL-C levels were significantly elevated whereas HDL-C and HDL/LDL ratio were found to
be significantly reduced in obese subjects when compared with controls. It is concluded that obese group having
higher level of adiposity may face far ranging negative effects on health.
NABILA ROOHI, JAVERIA MALIK, HIBA NAZIR, SAMINA ASHRAF, MUHAMMAD MANSHA. (2016) Levels of Inflammatory Markers and Lipid Profile in Obese Young Adults, Biologia – Journal of Biological Society of Pakistan, Volume 62 (I), Issue 1.
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