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Pakistan has the second highest rate of hepatitis C in the world, and it is estimated that 11.85 percent of its
population suffers from this medical problem. A valid and comprehensive scale was constructed to help for
quantification of neuro-psychological and physical side effects of different treatment regimens available for
eradication of hepatitis C infection. The present study was conducted in 3 stages. In stage I, item generation was
done empirically through detailed review of literature, detailed interviews with practicing physicians and focus
groups with patients. In stage II, factor structure of the scale was explored through exploratory factor analysis on
a sample of 250 HCV patients (M = 39.6, SD = 9.4, age = 18-60 years) and confirmed through confirmatory
factor analysis on a sample of 230 selected patients of HCV (M = 38.9, SD = 9.2, age = 18-60 years) which
resulted in 3 factors with 36 items. Physical factor contained 19 items related to physical complaints such as body
aches and anorexia. Psychological factor included 12 items, which were psychological complaints such as crying
spells and depression. Neuro factor had 5 items of neurological complaints in nature such as hallucination. In
stage III, psychometric properties of the scale were established and it revealed that it is a highly reliable scale
with r =.97. Physical, psychological and neurological factors of NPPSI-Scale also revealed high value of alpha
coefficient respectively .98, .95 and .92. Convergent and discriminant validity of NPPSI- Scale was also
established.
Naima Hassan, Amina Muazzam. (2019) Development and Validation of Scale for Neuro-Psychological and Physiological Side Effects of Interferon Therapy (NPPSI) in HCV Patients, Pakistan Journal of Social and Clinical Psychology, Volume 17, Issue 2.
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