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In the field of computational biology, electronic modeling of bio-cellular processes is in vogue for about a couple
of decades. Fast, efficient and scalable electronic mimetics of recurrently found bio-chemical reactions are
expected to provide better electronic circuit simulators that can also be used as bio-sensors or implantable biodevices at cellular levels. This paper presents some possible electronic circuit equivalents to model dynamics of
one such bio-chemical reaction commonly involved in many bio-cellular processes, specifically pathways in
living cells, known as the Hill process. The distinguishing feature of this process is cooperativity which has been
modeled in silicon substrate using a pair of transistors, one transistor driving current in the other the same way
ligand binding to one receptor site controls the binding affinity of the other receptor sites. Two possible circuits
have been proposed and compared to electronically model cooperativity of a Hill reaction. The main idea is to
exploit the natural analogies found between structures and processes of a bio-cell and electronic transistor
mechanics, to efficiently model fundamental bio-chemical reactions found recurring in bio-processes. These
circuits can then be combined and rearranged quickly to form larger, more complex bio-networks, thus
mitigating the intricacies involved in modeling of such systems.
Maria Waqas, Muhammad Khurram, S.M. Razaul Hasan. (2020) Analog Electronic Circuits to Model Cooperativity in Hill Process, Mehran University Research Journal of Engineering & Technology, Volume 39, Issue 4.
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