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Objective: To determine the association of pro-inflammatory markers with suicidality in patients suffering from
major depressive episode.
Study Design:Descriptive cross sectional study.
Place and Duration of Study: The study was conducted at department of pathology in collaboration with the
department of psychiatry, Pakistan Railway Hospital, Islamic International Medical College, Rawalpindi from
th th 18 April, 2017 to 17 March, 2018.
Materials and Methods: Seventy five subjects recruited through convenient non-probability sampling
technique were divided into three groups i.e. Group 1 (patients of major depressive episode with suicidality),
Group 2 (patients of major depressive episode without suicidality) and Group 3 included healthy controls.
Patients of major depressive episode and suicidality were diagnosed through Hamilton rating scale for
depression and beck scale for suicidal intention successively. Pro-inflammatory markers i.e. Interleukin-1ß,
Interleukin-6 and C-reactive protein were measured in the serum of all participants. Data was analyzed through
statistical package for social sciences version 21. Simple descriptive statistics (frequencies, percentages) were
computed for each categorical variable. Mean and standard deviation were calculated for the numerical data.
Independent t test and one way ANOVA was applied to determine the statistical significance. P value of < 0.05
was considered significant.
Results:Out of 75 enrolled patients, Pro-inflammatory markers i.e. Interleukin-1ß, Interleukin-6 and C-reactive
protein were raised in patients of major depressive episode with suicidality.
Conclusion: Pro-inflammatory markers i.e. CRP, IL-1ß and IL-6 are markedly raised in patients of major
depressive episode with suicidality. So, from the results it is concluded that pro-inflammatory markers have an
association with suicidality in patients of major depressive episode and treating inflammation in them can
improve their symptoms and reduce suicidal rate.
Aqsa Liaqat, Muhammad Nadim Akbar Khan, Athar Muneer, Ama tul Naval, Fakhra Noureen. (2019) The Association of Pro-inflammatory Markers with Suicidality in Patients Suffering from Major Depressive Episode, Journal of Islamic International Medical College, Volume-14, Issue-1.
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