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Objective: To determine the hepatoprotective effect of Nigella sativa seeds in Pyrazinamide induced hepatic
damage in albino mice.
Study Design: An experimental study.
Place and Duration of Study: The study was conducted in pharmacology department of Islamic International
Medical College, Riphah International University, in collaboration with National Institute of Health, Armed
Force Institute of Pathology and Pakistan Institute of Medical Sciences Islamabad, Pakistan.
Materials and Methods: A total of 68 male albino mice were included in the study. They were divided into 4
group's i.e, seventeen mice in each group. Group A (control group), Group B (Pyrazinamide only treated), Group
C (Pyrazinamide + Low dose Nigella sativa treated) and Group D (Pyrazinamide+ High dose Nigella sativa
treated). Group B, C and D received Pyrazinamide through gavage needle once daily for six weeks. Group C and
D received Nigella sativa along with Pyrazinamide through gavage needle once daily for six weeks. Blood
sampling (baseline, end of 3 and 6 weeks) was done to analyze serum ALT and AST levels. Data was analyzed by
using SPSS version 21.
Results: Pyrazinamide treatment for 6 weeks increased serum ALT and AST levels. Nigella sativa
administration along with Pyrazinamide for six weeks decreased the elevated levels of ALT and AST in C
and D groups.
Conclusion: Nigella sativa seeds exerted hepatoprotective effect by decreasing the raised levels of ALT
and AST in Pyrazinamide treated albino mice
Amtul Hafeez, Akbar Waheed, Neelofar Yousaf. (2019) Role of Nigella Sativa Seeds on Pyrazinamide Induced Hepatotoxicity, Journal of Islamic International Medical College, Volume-14, Issue-1.
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