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Metabolic Syndrome (MS) is diagnosed when three
out of five cardiometabolic risk factors are present
namely hyperglycaemia, low HDL-Cholesterol, high
1
triglycerides, systolic hypertension and obesity.
Presence of metabolic syndrome increases the risk of
cardiovascular diseases and type 2 diabetes mellitus
2
(T2DM). Other conditions have also been related to
metabolic syndromes e.g. cancer, sleep apnea,
polycystic ovary syndrome, thyroid disruptions and
3,4 others. There is a worldwide epidemic of MS,
Pakistan and some other developing countries are no
4
exception . Hypothyroidism can be overt or subclinical. Subclinical-hypothyroidism (SCH) is defined
when TSH values are more than 4.0 mIU/L but less
than 10 mIU/L with normal thyroid hormones (fT4
5,6 and fT3). The etiological factors for SCH and overt
disease are the same with a difference of severity of
the disease, so SHO is also called 'Mild
Hypothyroidism' as by definition SCH is only a
biochemical diagnosis and has nothing to do with the
presence or absence of clinical features of thyroid
disease. SHO has been shown to be much more
7
common as compared to overt disease. SCH
becomes a dilemma for the physician regarding the
question of treatment or waiting for the overt
8,9 disease. Amongst many concerned related to
hypothyroidism, a propensity for dyslipidaemia is of
great concern more so if the patients has other
cardiovascular risk factors, too. Khan et al (2018)
have recently shown that lipid parameters are
adversely affected in hypothyroidism as a continuous
function of increasing level of TSH. Lipid changes are
found to be more subtle in the subclinical
hypothyroid group than cases with overt
10 hypothyroidism. Most significant effect has been
shown to be on LDL-cholesterol, non-HDLcholesterol and urine albumin-creatinine ratio
Aamir Ijaz. (2018) Association of Hypothyroidism with Metabolic Syndrome, Journal of Islamic International Medical College, Volume-13, Issue-4.
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