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Background: To evaluate the effects and safety profile of Paroxetine on hot – flashes in post – menopausal
women.
Methods: It was prospective open label control clinical trial. This study is conducted in the Department of
pharmacology & Therapeutics in collaboration with the Department of Obstetrics & Gynecology JPMC. The
patients were selected from outpatients department (OPD) of Obstetrics & Gynecology. Duration of the
study was 12 month from January 2014 to January 2015. Enrolling 180 outpatients who had menopause with
hot flushes divided into three groups. The Greene Climacteric Score Scaling was applied to observe the
effects of 12.5mg, 20mg Paroxetine on frequency of hot flashes as compared to Placebo.
Results: Mean GCS scoring frequency in 12.5mg Paroxetine group at 12 week was 1.97±0.31 and the baseline
2.64±0.29. In 20mg Paroxetine mean GCS at baseline was 2.76±0.23 and 12 week 2.04±0.12. Where as in
Placebo mean GCS scoring frequency at 12 week was 2.80±0.24 and at baseline 2.76±0.24.
Conclusion: The frequency of hot flashes with Paroxetine 20mg and 12.5mg, is significantly reduced in post
menopauseal women as compared to Placebo.
Zareen Naz, Moosa Khan, Faiz Ahmed Siddiqui, Faiza Siddiqui. (2019) The Role Of Paroxetine In Postmenopausal Hot-Flashes Frequency Reduction, The Pakistan Journal of Medicine and Dentistry, Volume 8, Issue-1.
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