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Objective: To compare the efficacy of letrozole versus Clomiphene Citrate for successful pregnancy rate in patients with polycystic ovarian syndrome.
Study Design: Randomized Controlled Trial.
Place and Duration: Six months (10-08-2014 to 09-02-2015) at the department of obstetrics and Gynaecology Military Hospital Rawalpindi.
Methodology: A total of one hundred and eighty-four (n=184) female patients with age between 20-35 years who were diagnosed cases of the Polycystic ovarian syndrome with infertility of more than one-year duration were enrolled in the study. Patients were randomized into Group A, treated with Clomiphene Citrate and Group B treated with Letrozole and were assessed for positive pregnancy within next three menstrual cycles.
Results: Patients in both the groups were similar in their demographic characteristics. Patients treated with Letrozole showed significantly higher rates of successful pregnancies when compared with Clomiphene Citrate (46.7% vs 22.8%) (P<0.05). The rate of efficacy was significantly higher in the age group of 24-30 years and in women having infertility duration of 5-8 years. There was no successful induction in patients having more than 8 years duration of infertility
Conclusions: Letrozole was found to be more efficacious in terms of successful pregnancies rate in women with the Polycystic ovarian syndrome in this study.
Qurat Ul Ain Aslam, Ghana Shahid, Naila Mahboob, Fatima Amin, Saadiya Shabbir Khokhar. (2018) Comparison of Pregnancy Outcome in Infertile Women with Polycysticovarian Syndrome Using Letrozole Versus Clomiphene Citrate, Journal of the Society of Obstetrics and Gynaecologists of Pakistan , Volume-08, Issue-1.
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