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Various studies have reported that genetic variations in ADAM12 (a disintegrin and metalloprotease 12) gene lead to the development of the most common joint disorder Knee osteoarthritis (KOA). However, the studies’ outcomes are conflicting. Therefore, the relationships between the genetic variations and KOA risk were analyzed through the current meta-analysis. Following the comprehensive literature search, odds ratios (ORs) and 95% confidence intervals (CIs) were computed for the influence of ADAM12 polymorphisms in conferring KOA susceptibility. A total of eleven research articles, comprised of 7012 controls and 5180 cases, were found eligible for the final evaluation. The ADAM12-rs1871054 showed a significant association with the susceptibility to KOA under the dominant (OR 1.55, 95% CI 1.19–2.02, P = 0.001) and additive (OR 1.71, 95% CI 1.03–2.85, P = 0.04) models. The ADAM12-rs3740199 showed a positive association with the OA susceptibility under the dominant (OR 2.67, 95% CI 1.16–6.14, P = 0.02) and recessive (OR 0.28, 95% CI 0.14–0.59, P < 0.001) models in males. However, the rs1044122 and rs1278279 showed no associations with the OA predisposition in any of the genetic models. Hence, the current meta-analysis suggests that ADAM12-rs1871054 and rs3740199 have a significant association with KOA susceptibility.
Bushra Khan, Saba Aman. (2021) ASSOCIATION BETWEEN THE GENETIC VARIATIONS IN ADAM12 AND THE SUSCEPTIBILITY TO KNEE OSTEOARTHRITIS: AN UPDATED META ANALYSIS, , Volume 18, Issue 1.
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