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Present study was designed for investigating the serum levels of vitamin-D and calcium and their association in male subjects with/ without palpitations (P), premature atrial contractions (PACs) and premature ventricular contractions (PVCs) and to understand the pathophysiological significance of serum variations in patients with cardiac arrhythmia. Male subjects with palpitations (n: 30), premature atrial contractions (n: 30), and premature ventricular contractions (n: 31) were studied using ECG, Holter monitors recordings, echocardiography, vitamin D (ng/mL) and calcium (mg/dL) levels. The data was collected from out-patients Department of Cardiology, International Medical Center (IMC), Jeddah, Kingdom of Saudi Arabia (KSA). Vitamin-D status was determined by measuring the serum 25- hydroxyvitamin-D-(25 [OH] D levels, and serum calcium was determined by standard kit method. Serum levels of vitamin D and calcium in healthy male controls (C; n: 32) were assessed for comparison purposes. Comparison of serum vitamin D for all mentioned four groups showed significant variation among groups (Fs: 2.928; P = 0.037). However, individual comparisons indicated significant variations for PACs vs C (P = 0.0088) and PVCs vs C (P = 0.0388), though P vs PACs was close to significance (P = 0.0598). The other comparisons for P vs C, P vs PVCs and PVCs vs PACs showed non-significant variations. Comparison of serum calcium for all mentioned four groups showed highly significant variation among groups (F: 8.424; p = 0.00004). Whereas, the individual comparisons showed significant variations for the comparisons P vs C (P = 0.0014), PACs vs C (P < 0.0001), and PVCs vs C (P = 0002). The P vs PACs (P = 0.0748) was found not significant. The remaining two comparisons P vs PVCs and PVCs vs PACs gave non-significant variations. Association of vitamin D and calcium levels in normal healthy male subjects, and in patients with PACs and PVCs were found highly significant. The present studies suggest that serum vitamin D and calcium levels and their correlation in patients with cardiac arrhythmia have significant pathophysiological importance.
Dina M. Qahwaji , Abdulhalim S. Serafi. (2021) ASSOCIATION OF SERUM VITAMIN D AND CALCIUM IN PATIENTS WITH CARDIAC ARRHYTHMIA, , Volume 18, Issue 1.
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