• Ikram Din Ujjan

• D. Khan

• Aziz Ahmed Ujjan

• Ameer Ali Abro

• Farhatullah Kandhro

• Nisar Ahmed Khokhar

• Roohi Nigar Nizamani

تلخیص

This study describes the status of Hepatitis C virus (HCV) prevalence in outpatients of thirteen districts of province of Sindh, Pakistan. The blood samples of outpatients (OPs) were randomly collected from >80 thousand individuals of these districts during 2018 and the sera were studied at central diagnostic Laboratory LUHMS, Hyderabad. The antibodies screening showed 14.3% HCV prevalence in the OPs. The HCV antibodies level of more than 1.0 IU /100 µL) was considered to indicate HCV. OPs were more HCV positive in females (7.96%) than males (6.36%) of OPs. Geographically the HCV prevalence was higher at Mirpurkhas (22.0%), Jamshoro (21.7), Tando Allahyar (19.8) and Sanghar (19.0%). It was around 18% in Khairpur Mirs (18%) and N. Feroze (18.3%). In other districts it ranged from 10.2 (the lowest in Tharparkar) and 15.9% in Kashmore. The districts in hand may be arranged in following order on the basis of total % HCV prevalence. Mirpur Khas (22.0, the highest) ≈ Jamshoro (21.7) > Tando Allahyar (19.8) > Sanghar (19.0) > N. Feroze (18.3%) ≈ Khairpur Mirs (18) > Sukkur (16.0) ≈ Kashmore (15.9) ≈ Ghotki (15.6) > Dadu ((13.8) ≈ Badin (13.5) > Hyderabad (12.7) > Tharparkar (10.2, the lowest). The order of sequence of average antibodies level in HCV+ OPs of various districts was as follows: Tando Allahyar (60.8 ± 1.68 IU) > N. Feroze (55.5 ± 1.64 IU) > Jamshoro (48.71 ± 0.946 IU) ≈ Badin (48.14 ± 1.324 IU) ≈ Sukkur (47.3 ± 1.153 IU) > Ghotki (46.09 ± 2.915 IU) > Tharparkar (39.3 ± 3.11 IU) ≈ Khairpur Mirs (38.18 ± 1.983 IU) Hyderabad (21.10 ± 0.291 IU) > Dadu (17.60 ± 0.395 IU > Sanghar (15.9 ± 0.330 IU) > Kashmore (13.16 ± 1.146 IU) > Mirpur Khas (10.29 ± 0.296 IU). There was difference between severity and disease prevalence in the districts. Infants and Young population appeared to have some immunity against HCV. HCV prevalence, however, increased with age positively linearly or polynomially.

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