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Epilepsies are common chronic neurological disorders that affect approximately 500 million people world-wide, and are mainly characterized by recurrent seizures. There are a variety of factors that may influence the neural excitability and cause epilepsies. One of those factors is the increased serum homocysteine (Hcy). Hence, we planned to determine serum Hcy using enzyme linked immunosorbent assay (ELISA) in well age control matched non-obese adult epilepsy women (Ep; n: 41; age: 26-40 years) with tonic-clonic seizures so that we may predict the influence of seizure disorders on serum levels of Hcy. The Hcy serum levels (mean± SD) for Ep group (11.99 ± 2.97 μmol/L) were highly significant (p < 0.0001) as compared to those for control group (C; n: 39; age: 26-40 years; Hcy: 9.01 ± 3.09 μmol/L). Plot of age vs. serum Hcy in C group showed a positive linear relationship that indicated a highly significant correlation (R = 0.5101, p < 0.001). The plot of age vs. serum Hcy in Ep group showed a positive linear relationship that indicated a significant correlation (r = 0.3146, p < 0.05), though, this correlation was not so high significant in Ep group compared to one obtained for the C group subjects. Hence, significantly high serum Hcy levels and less association of Hcy with age in Ep group was investigated. The less association of Hcy with age in Ep group might be the effect of aging, antiepileptic drugs (AEDs), or seizures. The results in the present investigation provide newer and potential information for exploring further insights since hyperhomocysteinemia condition has a multifactorial origin.
Ahmed Almalki, Kausar A. Saldera, M. H. Hussain, Gisela H. Maia, Abdulhalim S. Serafi, Zahir Hussain. (2021) HOMOCYSTEINE SERUM LEVELS IN ADULT NON-OBESE WOMEN WITH EPILEPSY, , Volume 18, Issue 3.
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