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Estrogen serves as preischemic treatment for cerebral ischemia protection and hence it is considered as vasoprotective
and neuroprotective agent. The involvement of estrogen in epilepsy, ischemia, and other disorders has recently been
comprehensively reviewed. Premenstrual estradiol 17-β serum levels (pmol/l) (Mean ± SEM) using ELISA kits in
normal control (NC, n: 40) women subjects and women patients with ischemic stroke (IS, n: 37) and post-ischemic
stroke epilepsy (PISE, n: 36) were found respectively as 221.125 ± 10.3989, 201.9459±8.6548 and 237.9722 ±
12.2337. Statistical analysis showed non-significant results for NC vs. IS and NC vs. PISE whereas IS vs. PISE showed
significant variations (p=0.0183). One way ANOVA and Tukey-Kramer test for normal control subjects (NC) and
subjects with ischemic stroke (IS) and post-ischemic stroke epilepsy (PISE) demonstrated significant variations among
groups (Fs =2.856; p = 0.05). Tukey-Kramer test showed significant variations for ischemic stroke (IS) subjects vs.
post-ischemic stroke epilepsy (PISE) subjects. Stress and depression, lack of physical activity and personal or family
history of stroke or TIA presented significant difference (p < 0.05). Conclusively, more work is needed to be carried
out to understand the precise role of premenstrual estradiol in ischemic stroke and post-ischemic stroke epilepsy.
Samir Mohammed Abdulfattah Attia, Yaser Hasan Bahakeem. (2019) PREMENSTRUAL ESTRADIOL LEVELS IN FEMALE PATIENTS WITH ISCHEMIC STROKE AND POST-ISCHEMIC STROKE EPILEPSY, , Volume 16, Issue 2.
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