• Samir Mohammed Abdulfattah Attia

• Yaser Hasan Bahakeem

• Nazish Iqbal Khan

• Zahir Hussain

• Mamdouh H. Kalakatawi

• Hani Faidah

• Lubna Naz

• Ghazala Yasmeen

• Samia Mushtaq

• Amal Alkhotani

• Huma Zahir

• Adil Atia Samran Allahaibi

• Turki Hilal Atawi Alhassani

• Malek Hameed Ahmed Al-Harbi

• Mohammed A. Bafail

• Abdulhalim S. Serafi

تلخیص

Ischemic stroke occurs due to lack or interruption of blood supply to brain mainly due to blockade of a blood vessel. The present report provides further information about the concentration and interrelationship of LDL cholesterol (LDLC) and homocysteine (Hcy) in normal healthy women and women patients with ischemic stroke. Clinical diagnosis and management of the patients was carried out and complete history was recorded. The LDL-C, Hcy and other physiological/ biochemical measurements were carried out by kit methods mainly ELISA kits. The LDL-C serum levels (mg/ dl) in female patients with ischemic stroke and normal healthy female controls were 110.45± 2.09 (n:24) and 89.05±2.88 (n:21) respectively. Statistical comparison showed highly significant variations (p< 0.0001). Serum Hcy levels (μmol/L) in female patients with ischemic stroke and normal healthy female controls were 9.33±0.54 (n:24) and 7.74±0.35 (n:21) respectively. Statistical comparison showed highly significant variations (p = 0.0161). The Hcy plotted against LDL-C did not show any significant linear relationship in normal healthy women but a highly significant linear correlation (slope: 3.3191; R² =0.7457; p-value= 4.63E-7) was found in women patients with ischemic stroke. The present study provides interesting investigations and will hence be helpful for carrying out further studies especially to understand the beneficial role of factors for reducing LDL-C and Hcy for better management of patients with ischemic stroke and related disorders.

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