Methicillin resistance of 163 strains of Staphylococcus aureus isolated from nasal cavity was determined by disc diffusion method. The incidence of methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA) was noted as 128 (78.5%) and 35 (21.5%) respectively. The inhibition efficacy of decoction, infusion and essential oil of Origanum vulgare (oregano) was assayed against all isolates, using well diffusion assay. All the isolates were found resistant to decoction and infusion whereas the essential oil of oregano exhibited antibacterial activity against 124 (96.88%) MSSA and 28 (80%) MRSA isolates. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of oregano oil against MSSA and MRSA was same. It was noted as 0.31-2.5%,(v/v).