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Today I am writing to highlight a new Pakistani health crisis - The rise of typhoid "superbug"! Typhoid fever remains a significant public health threat in low- and middle-income countries, with an estimated 11–20 million cases and between 128 000 and 161 000typhoid-associated deaths each year.1–4Pakistan has been a high burden country for typhoid with severe disease, very high incidence especially among 2–15 year-olds, and more importantly a high resistance pattern.5,6As a clinician,managing typhoid was easy in days gone by but not anymore. Simple first line oral antibiotics lost efficacy in 1980s as management became more complicated by increasing rates of multi-drug resistance (MDR) strains of Salmonella (S) species (Typhiandparatyphi A, B and C). Increasingly high fluoroquinolone resistance rates (>90%) has been observed in these Salmonella species probably because of its widespread misuse.5
Ejaz Ahmed Khan,. (2019) XDR TYPHOID: THE PROBLEM AND ITS SOLUTION, JOURNAL OF AYUB MEDICAL COLLEGE ABBOTTABAD, Volume 31, Issue 2.
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