Abstract
Objective: To compare efficacy and safety of intranasal Midazolam with intravenous Diazepam for control of acute seizures in
children
Study Design: Randomized Control Trial
Place and Duration: Department of Paediatrics, Fauji Foundation Hospital, Rawalpindi for a duration of 6 months from 2nd July to
31st December 2018
Methodology: Children between the ages of 3 months to 12 years presenting during a seizure episode were randomized into two
groups. In Group A, patients were given 0.2mg/kg intranasal Midazolam administrated as drops in both nostrils. In Group B, patients
were given 0.3mg/kg Diazepam intravenously. Sedation levels and vital signs were noted before, after 5 minutes and 10 minutes of
administration of the two drugs. The time duration from arrival of patient in the hospital to start of treatment, and from
commencement of treatment to cessation of seizures was recorded and compared between the two groups.
Results: Results showed that the mean time from arrival at hospital to start of treatment was significantly shorter (p <0.05) in the
Midazolam group as compared to the Diazepam group (2.07+0.27 vs. 5.06+0.81 minutes). The mean time to control seizures after
arrival in hospital was also significantly shorter (<0.05) in IN Midazolam group in comparison to Diazepam group (5.43+2.82 vs.
7.66+2.39 minutes). No serious adverse side effect was observed in Midazolam group.
Conclusion: Intranasal Midazolam is an effective noninvasive method for control of acute seizures in children.
SeizuresIffat Batool, Hasan Mujtaba, Farah Gul, Saba Savul, Huma Salim Khan , Uzma Ather. (2020) Comparison of intranasal midazolam with intravenous diazepam for treatment of acute seizures in children: A randomized controlled trial, Isra Medical Journal, Volume 12, Issue 1.
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