Abstract
Objective: To compare the efficacy and safety of Intracameral Cefuroxime and Moxifloxacin in preventing postop endophthalmitis in
rural areas.
Study Design: A Randomized controlled trial
Place and Duration: At Layton Rehmatullah Benevolent Trust (LRBT) Free Secondary Eye Hospital, Akora Khattak, from 1st January
2010 till 31st January 2011.
Methodology: Patients undergoing cataract surgery were randomly distributed in three groups A, B and C. Group A underwent
routine aseptic technique of phacoemulsification without Intracameral antibiotic injection of any kind. Group B after routine
phacoemulsification received an additional Intracameral Cefuroxime injection in the dose of 1mg/0.1ml at the end of surgery while
Group C after routine phacoemulsification received Intracameral Moxifloxacin 5%. Patients were followed for four weeks post
operatively and frequency of Endophthalmitis was noted in the patients. Post-operative visual acuity and reaction in the anterior
chamber was also noted.
Results꞉ A total of 908 patients were operated for cataract surgery during this period. The mean age of patients in all the groups was
60 years and 56% of the patients were males. The frequency of post op endophthalmitis was 1.2% in Group A, whereas the
frequency was 0% in both Group B and C. There was trace to +1 cells in the anterior chamber on the first post op day in 84% of
patients in the group A, 97% of patients in group B and 95% of patients in group C. However, there was no reaction one week post
op in 95% of patients in group A, 98.8% of patients in group B and 97.8% of patients in group C. Initial results reflected that there
were fewer cases (P <0.05) of post op endophthalmitis following Intracameral antibiotic injections.
Conclusion: Intracameral use of cefuroxime and moxifloxacin is effective in controlling post-operative endophthalmitis in rural
Pakistan with high frequency of cataract surgeries without untoward side effects.
Ayisha Shakeel, Sharjeel Sultan, Syed Imtiaz Ali. (2020) Comparison of Post-operative Endophthalmitis prophylaxis using Intracameral cefuroxime and moxifloxacin in rural Pakistan- A randomized controlled trial, Isra Medical Journal, Volume 12, Issue 1.
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