• Shahneela Siraj

• Meraj Raheem

• Masood Anwar Qureshi

• Durr e Sameen Kamran

• Naila Parveen

• Afshan Mehboob Khan

Abstract

Objective: To measure serum insulin levels and anthropometric indices of the macrosomic neonates and to associate them with maternal glycemic factors Methodology: This multi-center cross-sectional study was conducted in various hospitals in Karachi from November 2011 to February 2013 and included 125 macrosomic neonates. Mothers were grouped as diabetic and non-diabetics. Anthropometric parameters of baby were measured in addition to blood markers like cord blood insulin. Results: Comparison of anthropometric indices showed statistically significant higher values of h e a d c ir c u m f e r e n c e ( p=0 . 0 0 7 ), c h e s t c ir c u m f e r e n c e ( p = 0 . 0 1 5 ), a b d o m i n a l circumference (p<0.010), mid-upper arm (p<0.010) and bi-parietal diameters (p=0.035) in macrosomic neonates of diabetic mothers as compared to macrosomic neonates of nondiabetic mothers. Fetal serum insulin was increased in neonates of diabetic mothers as compared to that of non-diabetics. Conclusion: Hyperinsulinemia was found in increased frequency in macrosomic infants of diabetic mothers as compared to the nondiabetics. Newborns of diabetic mothers showed significantly higher bi-parietal diameter, head, c h e s t , a b d o m i n a l a n d m i d u p p e r a r m circumference. Abdominal circumference and mid upper arm circumference were significantly high in the macrosomic infants with hyperinsulinemia. (Rawal Med J 202;45:593-597).

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