Abstract
Background: Insulin resistance in pregnancy and gestational diabetes is an important cause of
mortality and morbidity. We aimed to compare serum insulin, Homeostatic Model Assessment of
Insulin Resistance (HOMA-IR) and serum adiponectin between normal non-pregnant and pregnant
women to see the correlation between adiponectin and insulin resistance in normal pregnant
women. Methods: This case control study was conducted at Army Medical College and Centre
for Research in Experimental and Analytical Medicine (CREAM) and Military Hospital,
Rawalpindi. Sixty subjects were recruited. Group I had 30 normal healthy women. Group II
consisted of 30 age and BMI matched 2
nd trimester pregnant women with normal glucose
tolerance. Women with diabetes, history of miscarriage or inflammatory disease were excluded.
ELISA was used to measure serum insulin and adiponectin levels. Glucose levels were measured
with glucometer. HOMA-IR was used to assess the insulin resistance (IR). Mean values were
calculated. Independent samples t-test was used to compare the means of the parameters. Pearson
correlation test was applied to evaluate the correlation between variables in the groups, and p<0.05
was considered as significant. Results: Serum Insulin and HOMA-IR levels were significantly
different between group I and group II (p=0.000), however, serum adiponectin levels in both
groups were not significantly different. Small, non-significant negative correlation was observed
between serum adiponectin and HOMA-IR in group II (p>0.05). Conclusion: Non-significant
negative correlation between serum adiponectin and HOMA-IR reveals that there might be factors
other than serum adiponectin leading to IR in pregnant women
Javaria Sharafat, Maria Gill, Sara Naeem, Tallat Naureen, Sidra Arshad. (2020) DECIPHERING ADIPONECTIN-INSULIN RESISTANCE NEXUS IN NORMAL PREGNANT VERSUS NON-PREGNANT WOMEN, Pakistan Journal of Physiology, Volume 16, Issue 2.
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