Abstract
Preservatives have been used since prehistoric times and today is a recurring topic
in world debate. Paraben is among the top class preservatives used in food, pharmaceutical
agents, drinks, beautifying agents and numerous different items. So purpose of study was to
determine the possible hepatic and nephrotoxic effects of Butyl paraben in mice and to explore
the possible curative and protective impacts of turmeric. Fifty mice randomly divided in five
groups, i.e. Control, dose group (BP), dose and antidote group (BP+AD), vehicle control group
(VC) and antidote group (AD). A sub lethal concentration containing 15ug/g B.W of BP was
given with and without turmeric orally, dissolved in corn oil, used as vehicle too. Dissections
were made on 31st day, twenty-four hours after the last dose administration. Results showed that
continuous administration of butyl paraben (BP) had decreased the organs weight as compared
to control. Regarding biochemical parameters results had shown an increased enzymatic level
of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and
a significant increase in bilirubin levels in BP group. Significant raised patterns were recorded
for urea and creatinine in BP intoxicated mice against control. Histological defects observed
were necrosis, pyknosis, increased sinosuidal spaces, portal hypertension, glomerulosclerosis,
abnormal vascular pole in liver and kidney respectively. But when turmeric powder was
coadministered with BP, these damages were reversed to a great extent. So, this study has
proved the protective role of turmeric against toxicity induced by BP in female albino mice.
Chaman Ara, Asmatullah, Zainab Riaz, Memoona, Asma Chaudhary, Shagufta Andleeb. (2020) Turmeric Plays Protective Role against Paraben Induced Hepatic and Renal Lesions in Albino Mice, Punjab University Journal of Zoology, Volume 35, Issue 1.
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