Abstract
Objective: To assess the diagnostic efficacy of oral brush cytology in the diagnosis of potentially malignant and
malignant lesions of the oral cavity.
Study Design: Cross-sectional analytical study.
Place and Duration of Study: Outpatient Department of ENT and Maxillofacial Surgery, Pakistan Institute of
st Medical Sciences and Pathology Department of Pakistan Railway Hospital Rawalpindi from 1 March 2017 to
th 28 February 2018.
Materials and Methods: A total of 50 patients with oral lesions were enrolled through non-probability
convenient sampling. All patients presented with oral potentially malignant lesions were included, while
patients with age less than 10 years and with bleeding diathesis were excluded from the study. The oral lesions
were first sampled by oral brush biopsy technique using a toothbrush and then later on by scalpel biopsy.
Samples were then studied under microscope for diagnosis. The data was analyzed using SPSS software version
21.0. Sensitivity, specificity, positive predictive value and negative predictive values were calculated keeping
histopathology as a gold standard. Pearson's Chi-Square Test was used for calculating p-value, where p-value of
≤ 0.05 was considered significant.
Results: In this study, the mean age of patients presented with non-malignant oral lesions was 59 ± 12 years,
while those with oral cancers were 60 ± 12 years. Men were affected than women. Among 50 patients 39 were
found to have oral cancers. The sensitivity of oral brush biopsy was 88%, specificity was 83.3%, positive
predictive value was 97.6% and negative predictive value was 50%. The p-value was calculated as 0.001, which
was significant.
Conclusion: Our study found that oral brush cytology is reliable and can be easily performed with less cost and
discomfort to the patient. It can be used for screening of suspicious oral lesions. It is useful in those situations
where a patient refuses to have a biopsy or where a patient with bleeding diathesis would be exposed to
unnecessary surgical risks
Umer Muhammad Azam Khan, Siyab Ahmad, Samina Altaf, Madiha Sajjad, Huma Sabir Khan. (2020) Comparison of Oral Brush Cytology and Tissue Biopsy in Diagnosing Oral Lesions, Journal of Islamic International Medical College, Volume-15, Issue-2.
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