Abstract
Objective: To determine the effects of ginger extract on the histomorphological changes of fatty liver of hyperlipidemic
diet induced NAFLD.
Study Design: It was randomized control trial.
Place and Duration of Study: The study was carried out from October 2012 to March 2013, in the department of Anatomy,
Islamic International Medical College, Rawalpindi, in collaboration with National Institute of Health (NIH),
Islamabad.
Materials and Methods: A total of 35 male albino mice were used and divided into 3 groups. The control group (C) was fed
on normal laboratory diet, while the remaining two groups, fatty group (FG), ginger group (GN), were fed on
hyperlipidemic diet for twelve weeks to induce hyperlipidemia/nonalcoholic fatty liver. Then GN group with induced
hyperlipidemia/ fatty liver was administered normal laboratory diet with ginger extract as a drink in replacement of water
for another twelve weeks.
Results: Total body weight was reduced as compared to their initial body weights. The histological examinations of this
study revealed reverse fatty (steatotic) changes and showed marked reduction in number of fat globules, ballooning
degeneration, glycogenated nuclei.
Conclusion: This research shows that ginger extract has marked antihepatotoxic effects. Ginger extract ameliorates high
fat induced fatty liver disease.