Abstract
Objective: To compare the complete healing of chronic anal fissure by using 2% nifedipine paste and 0.5%
glyceryl trinitrate ointment each applied locally for 6 weeks.
Study Design: Randomized Controlled Trail.
Place and Duration of Study: Surgical Unit-I, Pakistan Railway Hospital Rawalpindi spanning over a period of
06 months starting from March 2011 toAugust 2011.
Materials and Methods: Seventy six patients of chronic anal fissure were included in the study. Non-probability
convenience sampling was used for the enrolment of patients. Patients were divided equally into two treatment
groupsA& B. Group 'A' was treated with topical 2% nifedipine paste and Group 'B' was treated with 0.5% glyceryl
trinirate ointment. Patients were asked to come for the follow up after six weeks to look for symptomatic
improvement and healing rate.
Results: All 38 patients included in the study completed the follow up after 06 weeks of treatment in either group.
Three patients from Group B experienced intractable headache and were managed by analgesics accordingly
but they went on to complete the treatment. None of the patient in group A had any significant side effect causing
any adjustment in the treatment. At the end of 06 weeks of treatment, 28 patients in Group A and 25 in Group B
showed complete healing of anal fissure. The overall healing rate was 69.75 %( n=76). There was statistically no
significant difference at the end of 06 weeks of treatment (p=0.454).
Conclusion: It is concluded that 2% nifedipine paste is as effective as 0.5% GTN ointment in terms of healing of
chronic anal fissure.
Maliha Yunus, Mumtaz Akhtar, Zeeshan Ghani. (2013) Comparison of Topical Glyceryl Trinitrate and Nifedipine in Management of Chronic Anal Fissure, Journal of Islamic International Medical College, Volume-8, Issue-1.
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