Abstract
Objective: The objective of this study was to observe changes in spermatogenesis in the testes of albino rats
exposed to lead acetate.
Study Design:An experimental animals study
Place of Study and Duration: This study was carried out in the Department of Anatomy, Islamic International
Medical College Rawalpindi and at National Institute of Health Islamabad from January toApril, 2009.
Materials and Methods: Male adult rats were exposed to lead acetate with intraperitoneal dose of 4mg/Kg body
weight for 5 days a week for 6 weeks. The animals in groupAwere used as control. The animals of groups B were
treated with lead acetate with specified dose for 6 weeks. After 6 weeks the animals of subgroup B were
sacrificed. The results of these two groups were then compared.
Results: After six weeks, it was observed that the number of spermatogenic cells had decreased in the test
groups as compared with control group (p<0.05).
Conclusion: Lead is toxic for cells of spermatogenic series, injurious to heaith and plays a significant role in
reducing male fertility.
Dr. Saffia Shaukat, Dr. Shabana Ali, Dr. Fatima Riaz. (2011) Effects of Lead Toxicity on Spermatogenesis in the Testes of Albino Rats, Journal of Islamic International Medical College, Volume-6, Issue-1.
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