Abstract
Objective: To determine the most common
microorganisms in the body secretions of patients
admitted in an intensive care unit (ICU) of a tertiary
care hospital and estimate antibiotic sensitivities
to those organisms.
Conclusion: Microorganisms with multidrugresistance
especially gram-negative ones are
increasing day by day. A high percentage of
resistance to the frequently used antibiotics
(cephalosporins, quinolones, and carbapenems)
was found. The antibiotics prescribed empirically
should be according to regularly updated
antibiogram. (Rawal Med J 202;45:17-21).
Results: Out of 95 patients, 69.5% were males
and mean age was 27.37±10 years. All patients
had positive bacterial cultures except one that was
of Candida albicans. Bacteria were mostly gramnegative
(85.3%, n=81) and the most frequently
encountered were Pseudomonas aeruginosa
(34.7%). Pseudomonas aeruginosa was most
sensitive to polymixin-B (17.8%, n=17). For
Acinetobacter baumannii, colistin (10.5%, n=10)
followed by cefoperazone/sulbactam (5.2%, n=5);
for Klebsiella pneumoniae, amikacin and
imipenem had equally highest sensitivity (8.4%,
n=8). For Staphylococcus aureus, amikacin
sensitivity was found in the majority (7.3%, n=7).
Methodology: In this cross-sectional study
performed in the medical ICU of Jinnah
Postgraduate Medical Center, Karachi, from
January to February 2019, 95 specimens were
collected from blood, endotracheal secretions,
central catheter tips, and urine. Antibiotic
sensitivity was tested by the disk diffusion method.
