Objective: To compare the short and long term intraocular pressure changes after intravitreal injections of triamcinolone acetonide and bevacizumab in diabetic macular edema cases presenting at Al-Shifa Trust Eye Hospital, Rawalpindi.
Study Design: A hospital based randomized clinical trial.
Subjects and Methods: The study was conducted from 01 Jan 2012 to 31st December 2012 on 60 patients with diabetic macular edema; 30 injected with intravitreal triamcinolone acetonide (IVTA) and 30 with intravitreal bevacizumab (IVB). IOP was recorded before injection, at 1week and 6 weeks after injections. All findings were recorded on proformas and results were analyzed using SPSS 13.0.
Results: Difference in mean IOP of the two groups was not significant at base line (p=0.765) and 1 week (p=0.560). At 6 weeks, mean IOP in IVTA significantly raised from its base line mean IOP (paired sample t test, p<0.001) and was also higher than mean IOP of IVB group at that follow up (independent sample t test p<0.001).
Conclusion: Although effect on IOP was not significant in short term but patients in IVTA group had significantly higher IOP at 6 weeks after injection. This warrents careful patient selection and regular monitoring of IOPs in cases treated with intravitreal injections.
Mahmood Ali, Furqan Ahmad Khan, Sarah Zafar, Farah Akhtar. (2014) Short and long term intraocular pressure changes after intravitreal injections of triamcinolone acetonide and bevacizumab in diabetic macular edema, , Volume-39, Issue-4.
