Abstract
The aim of this study was the synthesis of silver nanoparticles by the most common chemical reduction method and to investigate their effects on blood hematology and biochemical parameters in Albino Wistar female rats. For this purpose, sixteen female rats were randomly distributed in two groups (n=8). Group I was control and Group II served as test. The test group received silver-nanoparticles (500mg/kg) intraperitoneally twice a week for four weeks. After synthesis, silver nano-particles were characterized by Scanning Electron Microscopy. Significant dose related changes in body weights, in tissue weights, in hematology and biochemical parameters of female rats were noticed. Decrease in body weight and in tissue weight especially in liver and heart was observed. Decrease in white blood cells, granulocytes, lymphocytes, monocytes, Mean corpuscular Hemoglobin Concentration , Platelet Distribution Width, Peripheral lymphocytes count, Mean Platelet Volume and Red width Cell distribution were observed while increase in hemoglobin, Red Blood Cell, Mean Corpuscular Volume, Mean Corpuscular Hemoglobin , Hematocrit, Platelet and Platelet Crit were noticed. Similarly, reduced concentrations of glucose, cholesterol, HDL, LDL and triglycerides were found in the test group. Thus, administration of silver nano-particles at a dose of 500mg/kg body weight resulted in induction of toxicity in female rats.
