Abstract
Estrogen Receptor has been a great tumor marker for management of breast cancer. Although the accurate role of Progesterone Receptor in cancer patients management has not been established, the pathologists, guidelines have recommended for routine measurement of Progesterone Receptor with Estrogen Receptor in breast cancer patients. A total sample of 160 cases with primary Breast cancer was prospectively studied over a period of 5 years in KIRAN (Karachi Institute of Radiotherapy & Nuclear Medicine), Pakistan. In the present study, we have analyzed the rate of occurrence of HER-2/neu (Human epidermal growth factor receptor-2), CA 15-3(Cell surface associated Mucin-1) and Steroid Hormone Receptors in breast carcinoma patients. Summary measures were calculated for various demographic and biochemical parameters and a correlation was calculated between Tumor Markers and Steroid Hormone receptors using Kruskal Wallis H test. A statistically significant difference in Her-2/neu levels between the different hormonal receptor expression groups was found with a p value of < 0.05. Based on our present data analysis we suggest that, the combination of HR (hormone receptor) and Her -2/neu is useful for routine breast cancer diagnostics.
