Home Journal List International Journal of Biology and Biotechnology Volume 12 Article Details

Abstract
Breast cancer is the commonest type of malignancy in the female population of Pakistan. The rationale of this study is to present the institution based breast cancer incidence in last 13 years and pattern of breast lumps to evaluate the association between tumor grade, metastasis in lyph nodes and other predictive aspects like tumor size and appearance of estrogen, progesterone (ER/PR) receptors and Her2/neu in one year. Out of 28487 cancer patients 5667 were registered as breast cancer patients at KIRAN from 1st January 2000 to 31 December 2012. Male breast cancers accounted for 93 (1.64%) and female breast cancers were 5574 (98.3%). The age standardized rate (ASR) of female breast cancer is 37.13 which are highest among all cancers and the ratio is highest in the region. One year prospective analysis of 568 breast cancer patients studied for their clinicopathological profile in which 554 (97.5%) were female and 14 (2.4%) were male patients. TNM classification indicates that majority of patients were at stage III and IV (6% at stage I, 20 % at stage II, 50 % at stage III and 23 % at stage IV). Majority of the cases (84%) have infiltrating ductal carcinoma (IDC) followed by in infiltrating lobular carcinoma (ILC) (11.4%) and only 4.4 % are rare carcinomas. Tumor grade I comprised only 5.6% and grade II was 59% and grade III was 35%. Hormone receptors (ER/PR) are positive in 50% of cases (ER/PR positive in 300 cases, only ER positive in 65 cases and only PR positive in 35 cases while ER/PR negative in 104 cases). Her2/neu showing high grade nuclei is positive in 226 cases while negative in 230 cases. Since majority of patients present late with advanced disease, there is a great need for breast health awareness to decrease the burden of advanced disease.

Keywords

Muhammad Hanif, Bushra Sabeen, Amir Maqbool, Akhtar Ahmed, Farkhanda Nadeem, Salman Habib. (2015) BREAST CANCER: INCIDENCE (THIRTEEN YEAR DATA ANALYSIS) AND ONE YEAR CLINICOPATHOLOGICAL DATA OF PATIENTS IN A TERTIARY CARE CANCER HOSPITAL, , Volume 12, Issue 3.
  • Views 448
  • Downloads
Previous Article 
Next Article  

Article Details

Journal
International Journal of Biology and Biotechnology
Volume
Volume 12
Issue
Type
Language


Recent Volumes