Abstract
The present work was designed to investigate the changes in some hematological, biochemical parameters and lipid profile as well as possible protective role of vitamin C and E against gasoline vapours induced male rats. The rats exposed to gasoline vapours were divided into 4 groups: group-1 treated with gasoline vapours only, group-2 treated orally with 200 mg/kg body weight of vitamin C and group-3 treated with 150 mg/ kg body weight of vitamin E and group-4 treated with vitamins C and E. The duration of the treatment was 6 weeks. Fasting blood samples were collected serum were prepared for estimation of some haematologic parameters (Hb content, PCV, RBCs count and lipid profile (total cholesterol, triglyceride (TGs), (HDL-C), (LDL-C) and (VLDL-C). Liver function was assessed by measuring the activities of liver marker enzymes (alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)). Total serum protein (TSP) and albumin were measured. The present results showed that gasoline vapours caused significant (p 0.05) decrease in TSP and albumin concentration and significant (p 0.05) increase in serum ALP, ALT and AST activities in comparison with the control group. Also, exposure to gasoline vapours induced significant (p 0.05) decrease in Hb, PCV, RBC and significant (p 0.05) increase in TC, TGS, LDL-C and VLDL-C and decrease in HDL-C compared to control. However concomitant treatment with gasoline vapours and administration of vitamins C and E exhibited a protective role on the observed toxic effect of gasoline vapours in male rats. The results of the present study indicated that toxic effects of gasoline vapours may be reduced by dietary supplementation of vitamins C and E.
