Abstract
Acute oral toxicity and efficacy study of poly herbal drug was carried out in albino rats and rabbits respectively to assess its effects on
gross behavior, body weight, biochemical and hematological parameters. Animals of the Test group were fed with the test drug,
animals of positive control group were fed with standard multivitamin tablet “Unicap” and animals of negative control group received
distilled water i.e. vehicle only. Autopsy findings showed no gross changes in vital organs and mortality during 30 days of study.
Significant increase in animal’s weight was noted in test drug treated groups. Biochemical analysis indicated the presence of all
essential minerals and trace elements in herbal preparation. The hemoglobin level was enhanced in the test drug treated animals as
compared to the groups fed with standard drug and vehicle clotting time, WBC and RBC count indicated that drug didn’t produce any
uncertain reaction in blood parameters. The sign and symptoms exhibited by chronic use were almost alike and confirm that the test
drug is a safe drug and have significant nutritional supplement value.
