Abstract
The non-bonded potential energies were computed for 2-[4-(5-Bromo-3-methyl-2-pyridyl) butylamino]-5-(6- methyl -3 - pyridyl - methyl) - 4 – pyrimidone, trihydrobromide , (Temalastine), which is the H1 receptor antagonist and sedative psychoactive in nature. In the present calculation all the possible pairs of non-bonded interaction have been included for the energy calculation. The present work describes the conformational analysis of temalastine by using kitaigorodsky function. The minimum potential energy was found to be -0.0089 k.cal/mol at 1 = 100o and 2 =300o . Allowed region is obtained for the Temalastin, using minimum potential energy, and the results indicates that possible allowed zone by using conformation for the Temalastin is 315o to 360o .
