The present study shows that sulfadiazine (SDZ) has greater capacity to bound with protein present in milk of goat. From this we calculated the percentage of drug in whole and skimmed milk. We also determined the amount of drug present in bound and free form. We also calculated the percentage of fat present in the milk samples. As the samples were collected from different rural areas of Faisalabad. We also determined the quality of the milk in these areas. The milk samples containing greater percentage of protein, showed the greater percentage of bound drug.