Urtica dioica (UD), as anti-inflammatory and analgesic, has been used by people in Iran since long. The aerial parts of plant containing active materials have been utilized in the prostate proliferative disease. In the present studies Methanolic extracts of Urtica dioica were prepared by maceration. Antinociceptive activity of the extract was determined by hot plate and writhing tests in mice. Methanolic extract of UD at 50 and 100 mg/ kg could produce 59% and 98% writhing inhibition respectively. Morphine (5 mg/kg) with 91% writhing inhibition showed less analgesic activity than UD (100 mg/kg). Number of writhings was decreased by diclofenac (50 mg/kg) in magnitude of 78% that was less than UD at 100 mg/kg (p < 0.05). Methanolic extract, in all test doses (25-100 mg/kg) showed a dose dependent increase in pain threshold in hot plate thermal test which were significantly higher than control. LD50 of UD was obtained 300 mg/kg. UD extract at 150 mg/ kg showed significant impairment in mouse coordination in the rota rod test.
M. Mahmoudi, M. A. Ebrahimzadeh, F. Pourmorad , S. Yasini. (2007) NTINOCICEPTION AND LOCOMOTOR IMPAIRMENT INDUCTION BY METHANOLIC EXTRACT OF URTICA DIOICA, , Volume 4, Issue 2&3.
