Abstract
The disposition kinetics, renal clearance and urinary excretion of ciprofloxacin in blood and urine were analysed by HPLC from 12 healthy male after oral dose of 500mg tablet. Urinary excretion was determined and disposition kinetic parameters were calculated by using one compartment open model. After single oral administration of ciprofloxacin the average AUC was 11.77 ± 0.92 h.mg/L, clearance(45.6 ± 4.30 L/h), distribution (86.9 ± 10.8 L), elimination half life (0.82 ± 0.08h), and MRT 0.59 ± 0.075h. Absorption rate constant was 3.54 ± 0.26h, with its half life 1.37 ± 0.19 and lag time 0.382 ± 0.01h. Correlation between renal clearance and diuresis was positive and 30.4% of administered drug was excreted in urine. The study supported the needs for the comprehensive evaluation of drug under indigenous conditions to obtain disposition kinetics renal clearance and urinary excretion on which the rational dose regimes of drug could be based.
