Abstract
Sulphonamide inhibits both gram positive and gram-negative bacteria. Septran is a combination sulphonamide drug of sulphamethaoxazole and Trimethoprim. The aim of our study was to study of complexation of naturally occurring inorganic elements with this drug. The complex formation of sulphamethoxazole with trace metal ions such as Fe (III), Cu (II), Co (II), Ni (II), Mn (II), Zn (II), Al (III) and Ca (II) were studied by potentiometric method. It was found that Mg (II), Ca (II) and Zn (II), Cu (II) showed identical behavior. All metals form complex at acidic pH as well as at basic pH, the comparison of septran DS drug with single trimethoprim compound, it was observed that septran is a combination drug it formed complexes at lower pH as compare to trimethoprim, which is not a combination drug and formed complexes at higher pH.
